The clinicopathological manifestations and differential diagnoses of mycosis fungoides variants (the great mimickers): a comprehensive review

Jacob Al-Dabbagh, Faculty of Medicine, Tishreen University, Latakia; Cancer Research Center, Tishreen University, Latakia, Syria Nemat Ismail, Faculty of Medicine, Tishreen University, Latakia, Syria Moath Alsoleman, Faculty of Medicine, Damascus University, Damascus, Syria Eman Mohammad-Deeb, Faculty of Medicine, Tishreen University, Latakia, Syria Lina Al-Soufi, Faculty of Medicine, Tishreen University, Latakia, Syria Zuheir Al-Shehabi, Cancer Research Center, Tishreen University, Latakia, Syria

Mycosis fungoides (MF) is the most prevalent type of primary cutaneous T-cell lymphoma (CTCL), which is considered a great imitator due to the wide spectrum of its clinical manifestations that can mimic numerous skin disorders. MF can also resemble a wide range of dermatoses on histopathological and clinicopathological bases. The various clinical and histopathological manifestations of MF often lead to missing or delaying the diagnosis, which leads to a poorer prognosis as a consequence. In this article, we presented a comprehensive review of the clinical presentations and differential diagnoses of the clinical, histopathological, and clinicopathological variants of MF with a focus on the histopathologic manifestations of each variant.