Lenalidomide and its impact on exanthematous reactions: a case report

Cristiana Vieira-Maia, General Family Medicine, USF Aquae Flaviae, ULS Trás - Os - Montes e Alto Douro, Chaves, Portugal José E. Ramos, General Family Medicine, USF Aquae Flaviae, ULS Trás - Os - Montes e Alto Douro, Chaves, Portugal Ana C. Morgado, General Family Medicine, USF Aquae Flaviae, ULS Trás - Os - Montes e Alto Douro, Chaves, Portugal

Lenalidomide is a drug used mainly in the treatment of Multiple Myeloma and Myelodysplastic Syndrome. Despite its therapeutic benefits, lenalidomide can cause several adverse effects, including exanthematous reactions that can appear unexpectedly and cause discomfort to the patient. These skin reactions can be mild or severe and sometimes require the discontinuation of the lenalidomide treatment. In this case study, we will present the case of an 86-year-old man with a history of multiple myeloma who was on his fifth cycle of lenalidomide 10 mg and dexamethasone 20 mg, who was seen at the Health Center for constipation after two visits to the emergency department. During the consultation, the objective examination revealed a scattered maculopapular rash, probably secondary to lenalidomide. Timely assessment and guidance in these situations can be crucial to the patient’s prognosis. Anamnesis is one of the fundamental pillars of medical diagnosis.

Keywords: Anamnesis. Adverse effects. Exanthema. Hypersensitivity. Late onset. Lenalidomide.