Vancomycin-induced drug rash with eosinophilia and systemic symptoms syndrome: a case report

Vikram Singh-Dhapola, Department of Pharmacology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, India Rakshit R. Singh-Deori, Soban Singh Jeena Government Institute of Medical Sciences and Research, Almora, India Rishabh Arora, Department of Pharmacology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, India

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an uncommon but potentially life-threatening cutaneous hypersensitivity reaction characterized by extensive mucocutaneous eruption, fever, hematologic abnormalities, including eosinophilia and/or atypical lymphocytosis, and extensive organ involvement. Here, we present a rare case of DRESS syndrome in a female patient with burn injuries, following vancomycin therapy for methicillin-resistant Staphylococcus aureus infection. According to the RegiSCAR diagnostic criteria, the case was classified as definite DRESS. Clinical resolution was achieved with the timely initiation of methylprednisolone and antihistamine therapy.

Keywords: Drug reaction with eosinophilia and systemic symptoms syndrome. Drug hypersensitivity syndrome. RegiSCAR. Vancomycin.