Multinucleate cell angiohistiocytoma: a rare and challenging diagnosis

Sara Bastos, Unidade de Saúde Familiar S. Félix/ Perosinho - Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia, Portugal Cíntia Pereira, Unidade de Saúde Familiar S. Félix/ Perosinho - Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia, Portugal Álvaro Duarte, Unidade de Saúde Familiar S. Félix/ Perosinho - Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia, Portugal Ana S. Nogueira, Unidade de Saúde Familiar S. Félix/ Perosinho - Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia, Portugal Rui M. Costa, Unidade de Saúde Familiar S. Félix/ Perosinho - Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia, Portugal Tiago Vilarinho, Unidade de Saúde Familiar S. Félix/ Perosinho - Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia, Portugal

Multinucleated cell angiohistiocytoma is a rare benign neoplasm of unknown etiology that progresses slowly. We report the case of a 50-year-old man with erythematous-violaceous papules and plaques on the dorsal aspect of his left hand, which gradually increased in size and evolved into subcutaneous nodules. Histopathological examination revealed a multinucleated cell neoplasm with vascular proliferation, consistent with multinucleated cell angiohistiocytoma. Given the absence of symptoms and benign nature, an active surveillance approach was adopted. This case emphasizes the importance of considering rare skin lesions in differential diagnoses and reinforces the value of multidisciplinary evaluation to avoid unnecessary interventions.

Keywords: Skin neoplasms. Histiocytoma. Benign fibrous.