Mafalda Pestana, Dermatology and Venereology Department, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Margarida Brito-Caldeira, Dermatology and Venereology Department, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal Victor Farricha, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Sara Carvalhal, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Joana Bartolo, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Cecília Moura, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Joaninha Costa-Rosa, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Emanuel Gouveia, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Hugo Nunes, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal Mariluz Martins, Skin Cancer Multidisciplinary Group, Instituto Português de Oncologia de Lisboa. Lisboa, Portugal


Epidermolysis bullosa (EB) represents a group of congenital disorders caused by mutations in skin structural proteins. Squamous cell carcinoma (SCC) is one major complication and the leading cause of death of several subtypes of EB. We report a case of a 38-year-old female patient with recessive dystrophic EB that underwent electrochemotherapy (ECT) for treatment of cutaneous SCC in the right foot. Two sessions were performed, in which the intravenous administration of bleomycin was followed by the local application of electric pulses. We verified a partial response in 8th week of follow up and a complete response in the 24th week.

 

ECT is a local treatment for cutaneous and subcutaneous tumors, mainly as palliative care for metastases. Studies have shown its effectiveness in primary tumors that are unresectable due to size and location, and it has been proposed as a new treatment modality for SCCs in EB with high overall response.



Keywords: Recessive dystrophic epidermolysis bullosa. Squamous cell carcinoma. Electrochemotherapy.