Eccrine spiradenoma: three case reports

Rafael B. Santos, Department of Dermatology and Venereology, Unidade Local de Saúde de São João, Porto, Portugal Maria J. Cruz, Department of Dermatology and Venereology, Unidade Local de Saúde de São João, Porto, Portugal Manuel B. Costa, Department of Dermatology and Venereology, Unidade Local de Saúde de São João, Porto, Portugal Filipe Cruz, Department of General Surgery, Unidade Local de Saúde de São João, Porto, Portugal Roberto P. Silva, Department of Pathology, Unidade Local de Saúde de São João, Porto, Portugal Elisabete Rios, Department of Pathology. Unidade Local de Saúde de São João, Porto, Portugal Carolina A. Leal, Department of Pathology, Unidade Local de Saúde de São João, Porto, Portugal João M. Magalhães, Department of Pathology, Unidade Local de Saúde de São João, Porto, Portugal Maria H. Bessa, Department of General Surgery, Unidade Local de Saúde de São João, Porto, Portugal

Eccrine spiradenoma is a rare benign adnexal tumor, usually presenting as a painful solitary cutaneous nodule. We report three histologically confirmed cases in male patients aged 38 to 62 years, with lesions located on the right arm, forearm, and anterior hemithorax. Only one patient reported pain, underscoring the variability of clinical symptoms. All tumors exhibited the classic biphasic cell population and basement membrane material, without atypia or mitotic activity. Case 1 also demonstrated lymphoid infiltrates and vascular ectasias, with EMA-positive neoplastic epithelial cells. This series highlights uncommon demographic and anatomical presentations and reinforces the importance of histopathological evaluation for accurate diagnosis of eccrine spiradenoma, particularly in atypical settings.

Keywords: Eccrine spiradenoma. Adnexal tumor. Skin nodule. Histopathology.